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Brian Fargo the co-creator of the Fallout series, went on record to confirm that the Vault Boy Thumbs-up depiction wasn't to see how close you are to atomic bomb blast (if it's bigger than your thumb you're in the radiation zone). Vault Boy simply has a 'Positive Attitude'
Deep in Oasis, at the northern edge of the map, you'll find Harold, a ghoul who has literally become one with a tree, now known as Bob. Harold first appeared as a mutated ghoul in the original two Fallout games, and his transformation into a sentient tree is one of the series' longest-running character arcs.
The wrecked survey ship USS Ozymandias off the coast of Point Lookout is more than a scavenging spot. Its name, the quest 'An Antique Land,' and the in-game Bysshe Company are all references to Percy Bysshe Shelley's poem 'Ozymandias', right down to using the poet's own middle name.
Find a miniature chess board somewhere in the Wasteland and you'll be able to pick up tiny Nuka-Cola bottles, bears, and gnomes. Carry only one at a time and they'll stay miniature-sized in your inventory, a strange little physics quirk players still swap tips about.
